The Cups or Cash for Girls (CCg) Trial is currently being conducted in Western Kenya. This trial is investigating whether giving school girls a menstrual cup, cash transfer, or both, has an impact on various deleterious outcomes. This trial offers a unique perspective on safety monitoring and this article discusses why safety monitoring is important in such a trial and how it is being tackled.
Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected populationby Global Pharmacovigilance
Trying to identify genetic biomarkers of nevirapine hypersensitivity.
Research in pregnant and breastfeeding women is a complex area, with both the wellbeing of the mother and child paramount. Careful monitoring of any intervention to treat, or prevent, illness is required to ensure the benefits outweigh any harms. Read this article to find out more and download some of the safety tools developed by experts from the Malaria in Pregnancy Consortium.
Although there is now a good research pipeline of antimalarial drugs in response to the rapid spread of drug resistant malaria, there is very little evidence on how these drugs should best be deployed. The ACT Consortium is a global research partnership of a number of eminent public health and academic institutions in Africa, Asia, Europe and the United States where our projects' Principal Investigators are based. Research focuses around four major themes relating to artemisinin-based combination therapies (ACTs), the first-line treatment recommended by the World Health Organisation for malaria - in Africa and Asia: targeting, access, quality and safety. Including safety as a theme was important as, despite the wide scale use of ACTs, little is known about their long-term effects and their use in vulnerable populations, such as those co-infected with HIV. Moreover, it is clear that there is a need to work towards the pooling of safety data from multiple studies to understand uncommon adverse drug reactions that may not be detected by individual studies.